Aim: In this study, the red cell lipids, serum trace elements and immunological markers in prostatic disease patients attending the Nephrology Department of Abia state University Teaching Hospital Aba were evaluated.METHODOLOGY: A total of one hundred and ten (110) adult males (aged 40-80years) comprising of (60) prostatic disease patients and fifty (50) normal subjects were recruited. The prostatic disease patients comprised of thirty (30) prostatitis, twenty (20) benign prostatic hyperplasia (BPH) and ten (10) prostate cancer patients. Red cell lipids, trace elements and immunological markers were determined on blood samples collected from the subjects between January 2017 and December 2020.RESULTS: Results obtained following analysis indicated a significant increase in red cell total cholesterol, red cell LDL-cholesterol, red cell Triglyceride and red cell phospholipids (P<0.05) compared to control subjects whereas red cell HDL-cholesterol were significantly decreased compared to control subjects (P<0.05) serum trace elements: copper were significantly decreased in prostatitis and BPH compared to control subjects (P<0.05) but no significant decrease in prostate cancer patients compared to control subjects (P>0.05). Serum iron and lead showed no significant difference in prostatic patients compared to control subjects. Serum manganese levels showed significant increase in BPH patients compared to control subjects (P<0.05) whereas prostatitis and prostate cancer patients showed no significant decrease (P>0.05) compared to control subjects. Globulin concentrations of prostatatic patients did not show significant increase in prostatic disease patients compared to control subjects (P<0.05).CONCLUSION: Lipids serves as a promoter of peroxidation, oxidative stress and oxidative damage which has been implicated in many diseases and immunological markers is an evidence of inflammation which is evidence and risk factors in development of prostatic diseases.
BPH-Benign Prostatic Hyperplasia, HDLC-High Density Lipoprotein Cholesterol LDLC-Low Density Lipoprotein Cholesterol, TAG- Triglyceride, Total Chol- Total Cholesterol
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.